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Reduce Protein
Aggregation in
TFF

Tangential Flow Filtration (TFF) is a crucial step in biopharmaceutical manufacturing that requires the highest possible protein yield. Conventional pump systems such as peristaltic or 4-piston diaphragm pumps cause protein degradation due to mechanically induced shear of valves and tube compression. Furthermore, such systems generate a pulsating flow, resulting in non-optimal filter performance and reduced flux.

Levitronix® pump systems are designed for demanding TFF applications where ultra low shear as well as a pulsation free and continuously controlled flow ensure the highest protein yield.
Benefits

Highest Protein Yield

No more protein aggregation

The magnetic levitation technology guarantees that no pump components come in contact with one another enabling a continuous and smooth flow. Additionally, the pump design ensures that no proteinis trapped or damaged by valve interaction or tube compression, eliminating virtually all shear.

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Protein activity and size at 10 lmin and 1.5 bar

Constant Transmembrane Pressure (TMP)

No flow fluctuations due to pressure pulsations

Levitronix® pump systems deliver a pulsation free flow, independent of actual flow or pressure. With optional pressure or flow sensors, the Levitronix® control unit will keep the pressure / TMP or flux constant, independent of fluid or filter properties.

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Pulsation of a Levitronix® pump system in comparison to a 4-piston diaphragm pump at 20 lpm and 2.5 bar

Intrinsically Safe

No pressure build up or tube rupture

Set and limit the maximum pressure according to your tubing specifications and you will be assured that your media is safe no matter what occurs in your hydraulic flow path.

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Safe media, no matter what occurs in your hydraulic flow path.

Cleanest Pump in and beyond Bioprocessing

Lowest particle shedding

TFF processes are generally at the end of the down stream process and any particle addition risks the purity of the final product. Due to the low shear factor plus no wear or mechanical contact between moving parts such as membranes or tubings, particle generation is eliminated. Levitronix® is the cleanest pump system and meets the purity demand of not only biopharma processes but also industries with much higher purity requirements such as semiconductor production.

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Cumulative particle size distributions at 16 lpm and 2.5 bar
Products
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Bioprocessing Pumps (Single-Use)

Low Shear Bearingless Pump Systems

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Bioprocessing Pumps (Multi-Use)

Low Shear Bearingless Pump Systems

Process Control Units

Intuitive Control of Pumps, Flow Sensors, and Other Components

Bioprocessing Inline Flow Sensors

Ultrasonic Single-Use Flow Sensors

Bioprocessing Clamp-On Flow Sensors (First Generation)

Non-Invasive Ultrasonic Flow Sensors

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Bioprocessing Flow Controllers

Low Shear Single-Use Flow Controllers

Bioprocessing Clamp-On Flow Sensors

Ultrasonic High-Precision Clamp-On Flow Measurement for Bioprocessing

Downloads
Application Brochure: TFF Application Video: Process Automatization in TFF Customer Testimonial (Webinar): Using Levitronix® Pumps in Various Unit Operations of The Microsphere Customer Testimonial (Webinar): The Effect of Pressure Pulsations on Filter Fouling in TFF Customer Testimonial (Webinar): Levitronix® Single-Use Pump Systems in Pilot Scale TFF Applications Customer Testimonial (Webinar): Shear Stress Investigations on Levitronix® Single-Use Centrifugal Pumps
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